Visit our FacebookVisit our InstagramVisit our TwitterVisit our LinkedIn
Visit our FacebookVisit our InstagramVisit our TwitterVisit our LinkedIn
Amplify practices    I
Fargo

X-linked juvenile retinoschisis

It is estimated that one in every 5000 to one in every 25000 males have X-linked juvenile retinoschisis. While this condition cannot be cured, there are options that can improve visual function.

X-linked juvenile retinoschisis in PRIMARYCITY

What is X-linked juvenile retinoschisis?

X-linked juvenile retinoschisis or x-linked retinoschisis is a genetic condition which affects boys and men. The condition is characterized by abnormal splitting of the retinal layers and is the leading cause of juvenile macular degeneration in males.

The condition usually begins in the first decade of life, and the initial visual acuity ranges from 20/60 to 20/120. In the first and second decades, visual acuity usually declines, but remains stable until the fifth or sixth decade. Patients may become legally blind by the sixth or seventh decade, i.e. their visual acuity falls below 20/200.

NEW GENERIC SITE

What can a low vision optometrist do to help you?

Having this condition makes everyday tasks, like reading, driving, grocery shopping, cooking, walking and recognizing others, difficult. If you or your loved one is suffering from this condition, our low vision optometrist will perform a low vision evaluation to determine the extent of your remaining vision. Our goal is to maximize your visual independence and enhance the quality of your life by recommending low vision aids based on the results of the eye exam. For instance, children can benefit from large-text books and high-contrast reading materials, while adults can utilize different types of magnifiers, tints, and adaptive softwares to assist them both at home and work.
Furthermore, low vision optometrists can make recommendations for different types of lighting, placement of lights, improving contrast, and reducing glare to make your life better.

Driving with juvenile retinoschisis

Low vision optometrists can help adults make the most of their vision. In most states, drivers with the condition can obtain restricted licenses if they wear bioptic telescopic lenses behind the wheel. A bioptic telescope consists of a pair of glasses with a telescope attached above your normal line of sight. These can be attached to your regular eyeglasses and can be used either for one or both of your eyes. Bioptic lenses magnify images just like binoculars and help you see things better. Using these lenses allows you to see things that are much further away, which is one of their main benefits.

See our page on the driving laws in STATE with low vision.

Causes

Mutations in the RS1 gene on the X chromosome cause X-linked juvenile retinoschisis. This gene produces a protein called retinoschisin. Proteins like this are essential for the development and maintenance of the retina. A lack of normal retinoschisin protein results in splitting of the retina layers, from which the term "schisis" is derived, disruption of inter-cell communication, and loss of vision.

Causes
Diagnosis

Diagnosis

X-linked juvenile retinoschisis is diagnosed through eye examinations using a variety of testing methods. In the majority of cases, people with this condition have reduced vision and schisis visible on examination and imaging, along with abnormal electroretinograms (a test which assesses the retina's function). Some individuals also have a family history of X-linked inheritance. Genetic testing is also available for it. This helps determine an accurate diagnosis as well as the likelihood of a child inheriting the disorder from their parents. The patient is more likely to understand which emerging treatments and clinical trials are most appropriate if they have an accurate diagnosis.

Diagnosis

Symptoms

Loss of visual acuity is one of the first signs of x-linked juvenile retinoschisis. Visual prognosis is generally good for uncomplicated cases, and a person may not lose much vision over their lifetime. Some patients may become legally blind.

It is also characterized by cystic macular lesions (like blisters) in the retina. The lesions can cause retinal thickness, which further aggravates vision loss.

Moreover, the disease can progress to vitreous hemorrhage, retinal detachment, and neovascular glaucoma, which might cause severe vision loss.

Treatment and management

While there is no cure for this disease, there are ways to slow the loss of vision and help you perform daily tasks and engage in social activities.

Clinical trials and experimental procedures

There are multiple clinical trials underway that are exploring options to treat juvenile retinoschisis. Many are utilizing cutting edge methods of gene therapy. For example, a National Eye Institute funded study explored the use of gene therapy by introducing a healthy RS1 gene into the cells of the eye to see if this improves the production of healthy retinoschisin in the eyes. The trial explored placing the gene in a non-disease-causing virus. 

Management through low vision eye exams

Long-term monitoring is required for patients with X-linked juvenile retinoschisis. The disease often progresses rapidly in childhood, so a child should be monitored frequently. In the teenage years to middle age, the disease usually stabilizes, at which point annual dilated fundoscopy exams are adequate. Those who are older are at higher risk for progression, vitreous hemorrhage, and retinal detachment. These patients should be closely monitored and/or treated. Annual exams with your low vision optometrist will ensure that you are maximizing your remaining vision and up to date on the latest developments that can improve your vision and life. 

Avoid sports

In patients with X-linked juvenile retinoschisis, it is suggested to avoid contact sports and other activities that can cause a hard blow to the head. By doing this, you minimize the risk of retinal detachment or eye bleeding.

Surgery

Surgery is rarely effective in treating X-linked juvenile retinoschisis because the disease only affects the inner layers of the retina. The surgery, however, may be of help to patients with complete retinal detachment.

Causes

Common Questions

Juvenile retinoschisis, RS1, X-linked juvenile retinoschisis, X-linked juvenile retinoschisis 1, X-linked retinoschisis, and XLRS1.
X-linked juvenile retinoschisis
cartoon

Summary

X-linked juvenile retinoschisis is a genetic condition that affects males. Having this condition makes everyday tasks, like reading, driving, grocery shopping, cooking, walking and recognizing others, difficult. Our goal is to maximize your visual independence and enhance the quality of your life by recommending low vision aids based on the results of the low vision eye exam. Patients visit our low vision clinic from all over STATE, and we are proud to be a leading low vision provider in , SECONDARY1, SECONDARY2, SECONDARY3.  You can schedule a low vision evaluation with our low vision optometrist at 111-222-3333 so that we can determine the best course of treatment for you.

Related Articles

Testimonials


22222

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.


Ilan 2

1111111

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.


Ilan

Blog

23fd6b60 Ad7d 11eb Abba 8f029dbfa5ce Shutterstock 1255404055

Discover effective treatment options for diabetic retinopathy; consult our eye care professionals to protect your vision and overall well-being

June 3, 2023

Treating diabetic retinopathy Treating diabetic retinopathy is a critical aspect of preserving vision and maintaining the overall quality of life for patients suffering from diabetes. Diabetic retinopathy is a common complication of diabetes that affects the blood vessels in the retina – the light-sensitive tissue at the back of the eye. According to the National […]

Read More
Picture Focused Serious Young Caucasian Female Teacher With Textbook Taking Off Glasses Narrowing Eyes Trying See Something Clearly Student Girl Eyewear Posing With Diary

Understanding Foggy vision

May 21, 2023

Is foggy vision troubling you? Let our experienced optometrist restore your sight – book an appointment today and see the difference! The term foggy vision often refers to a visual disturbance characterized by blurred, cloudy, or hazy vision, which can make seeing clearly challenging. As your local optometrist, we recognize the significance of maintaining optimal […]

Read More
6c9c7c94 592e 4cb8 A2a4 2b965a52f698

Vision Therapy for Nystagmus: Improving Visual Function and Quality of Life

May 15, 2023

According to the National Eye Institute, nystagmus affects approximately 0.24% of the general population in the United States. This means a whopping 720,000 individuals in the US face the challenges of nystagmus. How does Nystagmus Impact Vision?  Nystagmus(/neuro/uncontrolled-eye-movements-how-nystagmus-can-affect-your-vision-and-how-a-neuro-optometrist-can-help/) is a condition that affects the eyes, causing involuntary and rapid movements that can make it difficult […]

Read More
see all blogs

Contact Us To Amplify Your EyeCare

Fargo Logo
Working Hours

Monday - Saturday
Closed

Sunday
Closed

Insurances that we accept
For Patients
appointment
Call Us
Referrals
Assessments
NEW GENERIC SITE eyefile-adduserphone-handsetcalendar-fullarrow-uparrow-right linkedin facebook pinterest youtube rss twitter instagram facebook-blank rss-blank linkedin-blank pinterest youtube twitter instagram